Carcinogen dose-dependent variation in the transgene mutation spectrum in urethane-induced lung tumors in transgenic mice carrying the human prototype c-Ha-ras gene.

Mori, I; Yasuhara, K; Hayashi, S M; Nonoyama, T; Nomura, T; Mitsumori, K

Mori, I; Yasuhara, K; Hayashi, S M; Nonoyama, T; Nomura, T; Mitsumori, K.

Affiliation

Mori I; Drug Analysis and Pharmacokinetics Research Laboratories, C-81, Takeda Chemical Industries Ltd., 2-17-85 Juso Honmachi, Yodogawa-ku, Osaka, Japan. mori_ikuo@takeda.co.jp

Cancer Lett ; 153(1-2): 199-209, 2000 May 29.

Article in En | MEDLINE | ID: mdl-10779650

Subject(s)

Carcinogens/toxicity; Genes, ras; Lung Neoplasms/genetics; Point Mutation; Transgenes; Urethane/toxicity; Animals; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms/chemically induced; Lung Neoplasms/pathology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic

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Collection: 01-internacional Database: MEDLINE Main subject: Urethane / Carcinogens / Genes, ras / Point Mutation / Transgenes / Lung Neoplasms Limits: Animals / Female / Humans / Male Language: En Journal: Cancer Lett Year: 2000 Document type: Article Affiliation country: Japan Country of publication: Ireland

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