Onchocerciasis in Guatemala. II. Microfilariae in urine, blood, and sputum after diethylcarbamazine.
Am J Trop Med Hyg
; 24(1): 58-61, 1975 Jan.
Article
in En
| MEDLINE
| ID: mdl-1089368
Guatermalan volunteers with onchocerciasis were given a dose of diethylcarbamazine to learn if this caused migration of microfilariae of Onchocerca volvulus into urine, blood, and sputum. In 5 of the 10 volunteers, the num0ers of microfilariae in the urine increased considerably following the drug. In the same 5, relatively large numbers of microfilariae were observed in the blood and sputum specimens. Response in the remaining 5 was negligible. Four controls given a placebo did not respond. Interestingly, however, 2 control subjects had onchocercal microfilariae in their concentrated blood specimens and 3 control subjects had microfilariae in the sputum. Therefore, we believe that microfilariae, if searched for, may be found in other parts of the patient not normally associated with the infection.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Onchocerca
/
Onchocerciasis
/
Sputum
/
Urine
/
Blood
/
Diethylcarbamazine
Type of study:
Clinical_trials
Limits:
Humans
/
Male
Country/Region as subject:
America central
/
Guatemala
Language:
En
Journal:
Am J Trop Med Hyg
Year:
1975
Document type:
Article
Country of publication:
United States