Cytochrome P450-mediated metabolism and cytotoxicity of aflatoxin B(1) in bovine hepatocytes.

Kuilman, M E; Maas, R F; Fink-Gremmels, J

Kuilman, M E; Maas, R F; Fink-Gremmels, J.

Affiliation

Kuilman ME; Department of Veterinary Pharmacology, Pharmacy and Toxicology, Utrecht University, PO Box 80152, 3508 TD, The, Utrecht, Netherlands.

Toxicol In Vitro ; 14(4): 321-7, 2000 Aug.

Article in En | MEDLINE | ID: mdl-10906438

Subject(s)

Aflatoxin B1/toxicity; Cytochrome P-450 CYP1A1/metabolism; Cytochrome P-450 Enzyme System/metabolism; Liver/enzymology; Steroid Hydroxylases/metabolism; Aflatoxin B1/analogs & derivatives; Aflatoxin B1/biosynthesis; Aflatoxin M1/biosynthesis; Animals; Benzoflavones/pharmacology; Biotransformation; Cattle; Cell Survival/drug effects; Cytochrome P-450 CYP1A1/antagonists & inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors/pharmacology; Female; Ketoconazole/pharmacology; Liver/cytology; Liver/drug effects; Steroid Hydroxylases/antagonists & inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: Steroid Hydroxylases / Aflatoxin B1 / Cytochrome P-450 CYP1A1 / Cytochrome P-450 Enzyme System / Liver Limits: Animals Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2000 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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