Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase.

Shiraishi, A; Sakumi, K; Sekiguchi, M

Shiraishi, A; Sakumi, K; Sekiguchi, M.

Affiliation

Shiraishi A; Department of Biochemistry, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.

Carcinogenesis ; 21(10): 1879-83, 2000 Oct.

Article in En | MEDLINE | ID: mdl-11023546

Subject(s)

Antineoplastic Agents, Alkylating/toxicity; O(6)-Methylguanine-DNA Methyltransferase/deficiency; Adenoma/chemically induced; Animals; Cell Death/drug effects; Cyclophosphamide/toxicity; Dacarbazine/toxicity; Female; Lethal Dose 50; Lung Neoplasms/chemically induced; Lymphoma/chemically induced; Male; Mice; Mice, Knockout; Nimustine/toxicity; O(6)-Methylguanine-DNA Methyltransferase/genetics; Testis/drug effects; Thymus Neoplasms/chemically induced

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Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Agents, Alkylating / O(6)-Methylguanine-DNA Methyltransferase Limits: Animals Language: En Journal: Carcinogenesis Year: 2000 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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