Hyperinsulinemia enhances transcriptional activity of nuclear factor-kappaB induced by angiotensin II, hyperglycemia, and advanced glycosylation end products in vascular smooth muscle cells.

Golovchenko, I; Goalstone, M L; Watson, P; Brownlee, M; Draznin, B

Golovchenko, I; Goalstone, M L; Watson, P; Brownlee, M; Draznin, B.

Affiliation

Golovchenko I; Department of Medicine and Research Service of the Denver VA Medical Center, Denver, Colorado, USA.

Circ Res ; 87(9): 746-52, 2000 Oct 27.

Article in En | MEDLINE | ID: mdl-11055977

Subject(s)

Angiotensin II/pharmacology; Hyperglycemia/physiopathology; Hyperinsulinism/physiopathology; NF-kappa B/genetics; Alkyl and Aryl Transferases/antagonists & inhibitors; Alkyl and Aryl Transferases/metabolism; Animals; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation/drug effects; Enzyme Inhibitors/pharmacology; Genes, Reporter; Glycation End Products, Advanced/pharmacology; Insulin/pharmacology; Luciferases/genetics; Muscle, Smooth, Vascular/drug effects; Muscle, Smooth, Vascular/metabolism; NF-kappa B/metabolism; Phosphorylation/drug effects; Time Factors; Transcription, Genetic/drug effects; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Angiotensin II / NF-kappa B / Hyperglycemia / Hyperinsulinism Limits: Animals Language: En Journal: Circ Res Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

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