Anandamide and 2-arachidonoylglycerol inhibit fatty acid amide hydrolase by activating the lipoxygenase pathway of the arachidonate cascade.

Maccarrone, M; Salvati, S; Bari, M

Maccarrone, M; Salvati, S; Bari, M.

Affiliation

Maccarrone M; Department of Experimental Medicine and Biochemical Sciences, University of Rome "Tor Vergata,", Via di Tor Vergata 135, Rome, I-00133, Italy.

Biochem Biophys Res Commun ; 278(3): 576-83, 2000 Nov 30.

Article in En | MEDLINE | ID: mdl-11095952

Subject(s)

Amidohydrolases/antagonists & inhibitors; Arachidonic Acids/metabolism; Arachidonic Acids/pharmacology; Glycerides/pharmacology; Lipoxygenase/metabolism; Arachidonate 5-Lipoxygenase/metabolism; Endocannabinoids; Enzyme Activation/drug effects; Enzyme Inhibitors/pharmacology; Ethanolamines/pharmacology; Humans; Kinetics; Lipid Peroxides/metabolism; Lipoxygenase Inhibitors/pharmacology; Neuroblastoma; Polyunsaturated Alkamides; Prostaglandin-Endoperoxide Synthases/metabolism; Structure-Activity Relationship; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Arachidonic Acids / Lipoxygenase / Amidohydrolases / Glycerides Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2000 Document type: Article Affiliation country: Italy

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