Simvastatin inhibits noradrenaline-induced hypertrophy of cultured neonatal rat cardiomyocytes.

Luo, J D; Xie, F; Zhang, W W; Ma, X D; Guan, J X; Chen, X

Luo, J D; Xie, F; Zhang, W W; Ma, X D; Guan, J X; Chen, X.

Affiliation

Luo JD; Department of Pharmacology, Guangzhou Medical College, Guangzhou 510182, China. Central Laboratory, The First Military Medical University, Guangzhou 510000, China. joluoa@public.guangzhou.gd.cn

Br J Pharmacol ; 132(1): 159-64, 2001 Jan.

Article in En | MEDLINE | ID: mdl-11156573

Subject(s)

Adrenergic alpha-Agonists/pharmacology; Heart/drug effects; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Myocardium/cytology; Norepinephrine/pharmacology; Simvastatin/pharmacology; Adrenergic alpha-Antagonists/pharmacology; Adrenergic beta-Antagonists/pharmacology; Animals; Animals, Newborn; Cell Size/drug effects; Cells, Cultured; Fluorescent Dyes; Leucine/metabolism; Myocardial Contraction/drug effects; Myocardium/metabolism; Myocardium/ultrastructure; Prazosin/pharmacology; Propranolol/pharmacology; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Norepinephrine / Adrenergic alpha-Agonists / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin / Heart / Myocardium Limits: Animals Language: En Journal: Br J Pharmacol Year: 2001 Document type: Article Affiliation country: China Country of publication: United kingdom

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