Oxidative activation of indole-3-acetic acids to cytotoxic species- a potential new role for plant auxins in cancer therapy.

Folkes, L K; Wardman, P

Folkes, L K; Wardman, P.

Affiliation

Folkes LK; Gray Laboratory Cancer Research Trust, PO Box 100, Mount Vernon Hospital, Northwood, HA6 2JR, Middlesex, UK. folkes@graylab.ac.uk

Biochem Pharmacol ; 61(2): 129-36, 2001 Jan 15.

Article in En | MEDLINE | ID: mdl-11163327

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Indoleacetic Acids/pharmacology; Prodrugs/pharmacology; Animals; Antineoplastic Agents, Phytogenic/administration & dosage; Antineoplastic Agents, Phytogenic/metabolism; Biotransformation; Drug Delivery Systems; Drug Screening Assays, Antitumor; Horseradish Peroxidase/administration & dosage; Horseradish Peroxidase/metabolism; Horseradish Peroxidase/pharmacology; Humans; Indoleacetic Acids/administration & dosage; Indoleacetic Acids/metabolism; Lipid Peroxidation; Oxidation-Reduction; Prodrugs/administration & dosage; Prodrugs/metabolism; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Indoleacetic Acids / Antineoplastic Agents, Phytogenic Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2001 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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