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Immunopathologic characterization of the tissue response in endemic pemphigus foliaceus (fogo selvagem).
Santi, C G; Sotto, M N.
Affiliation
  • Santi CG; Department of Dermatology, University of São Paulo School of Medicine, Brazil.
J Am Acad Dermatol ; 44(3): 446-50, 2001 Mar.
Article in En | MEDLINE | ID: mdl-11209113
BACKGROUND: The research on endemic pemphigus foliaceus (fogo selvagem) has mainly focused on the humoral immune response, but little attention has been given to the function of cell-mediated immune response and the nature of the cellular elements of the tissue reaction in the lesions of fogo selvagem. OBJECTIVE: The purpose of this study was the immunophenotype characterization of the inflammatory cells as well as the expression of adhesion molecules and HLA-DR in the perilesional and lesional skin of fogo selvagem. METHODS: Twenty biopsy specimens of lesional and perilesional skin were analyzed by immunohistochemical techniques. The panel of monoclonal antibodies consisted of CD8, CD4, CD1a, HLA-DR, IL-2R, LFA-1, ICAM-1, and PAN-B. RESULTS: The semiquantitative analysis of the cell population revealed a predominance of CD4 T lymphocytes in the tissue response of perilesional and lesional skin. The population of epidermal Langerhans cells was decreased in lesional skin when compared with the perilesional skin, whereas CD1a(+) dermal dendritic cells predominated in lesional skin. Keratinocyte expression of ICAM-1 and HLA-DR was negative in both lesional and perilesional skin. CONCLUSION: The overall results suggest the participation of the cell-mediated immunity in endemic pemphigus foliaceus (fogo selvagem). The lack of keratinocyte ICAM-1 expression may be related to the pattern of cytokines secreted by the CD4(+) T cells of the tissue reaction in fogo selvagem.
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Collection: 01-internacional Database: MEDLINE Main subject: Cell Adhesion Molecules / Pemphigus / Immunity, Cellular Limits: Humans Language: En Journal: J Am Acad Dermatol Year: 2001 Document type: Article Affiliation country: Brazil Country of publication: United States
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Collection: 01-internacional Database: MEDLINE Main subject: Cell Adhesion Molecules / Pemphigus / Immunity, Cellular Limits: Humans Language: En Journal: J Am Acad Dermatol Year: 2001 Document type: Article Affiliation country: Brazil Country of publication: United States