Lung Neoplasms/genetics; Animals; Cell Transformation, Neoplastic/genetics; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human/genetics; Chromosomes, Human/ultrastructure; Cytokines/therapeutic use; Genes, Dominant; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Genetic Therapy; Growth Substances/genetics; Humans; Immunologic Deficiency Syndromes/etiology; Immunotherapy/methods; Loss of Heterozygosity; Lung Neoplasms/blood; Lung Neoplasms/immunology; Lung Neoplasms/metabolism; Lung Neoplasms/therapy; Metalloendopeptidases/antagonists & inhibitors; Neoplasm Proteins/antagonists & inhibitors; Neoplasm Proteins/immunology; Neovascularization, Pathologic/therapy; Oncogenes; Randomized Controlled Trials as Topic; Smoking/adverse effects; Tissue Inhibitor of Metalloproteinases/antagonists & inhibitors; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/immunology