PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis.

Krishna, G; Liu, K; Shigemitsu, H; Gao, M; Raffin, T A; Rosen, G D

Krishna, G; Liu, K; Shigemitsu, H; Gao, M; Raffin, T A; Rosen, G D.

Affiliation

Krishna G; Division of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, 300 Pasteur Dr., Stanford, CA 94305-5236, USA.

Am J Pathol ; 158(3): 997-1004, 2001 Mar.

Article in En | MEDLINE | ID: mdl-11238047

Subject(s)

Bleomycin; Diterpenes/pharmacology; Diterpenes/therapeutic use; Drugs, Chinese Herbal; Drugs, Chinese Herbal/therapeutic use; Immunosuppressive Agents/therapeutic use; Phenanthrenes; Pulmonary Fibrosis/drug therapy; Animals; Bronchoalveolar Lavage Fluid/chemistry; Cell Survival; Diterpenes/chemistry; Drugs, Chinese Herbal/chemistry; Epoxy Compounds; Fibroblasts/cytology; Fibroblasts/metabolism; Immunosuppressive Agents/chemistry; Inflammation/pathology; Lung/cytology; Lung/metabolism; Lung/pathology; Male; Mice; Mice, Inbred C57BL; Pulmonary Fibrosis/chemically induced; Pulmonary Fibrosis/genetics; Pulmonary Fibrosis/pathology; Transcription, Genetic/drug effects; Transforming Growth Factor beta/genetics; Transforming Growth Factor beta/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenanthrenes / Pulmonary Fibrosis / Bleomycin / Drugs, Chinese Herbal / Diterpenes / Immunosuppressive Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Pathol Year: 2001 Document type: Article Affiliation country: United States

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