Lymphocytes from autoimmune MRL lpr/lpr mice are hyperresponsive to IL-18 and overexpress the IL-18 receptor accessory chain.

Neumann, D; Del Giudice, E; Ciaramella, A; Boraschi, D; Bossù, P

Neumann, D; Del Giudice, E; Ciaramella, A; Boraschi, D; Bossù, P.

Affiliation

Neumann D; Dompé Research Center, L'Aquila, Italy.

J Immunol ; 166(6): 3757-62, 2001 Mar 15.

Article in En | MEDLINE | ID: mdl-11238617

Subject(s)

Autoimmune Diseases/immunology; Interleukin-18/physiology; Receptors, Interleukin/biosynthesis; Animals; Autoimmune Diseases/metabolism; Autoimmune Diseases/pathology; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/metabolism; Cell Line; Cells, Cultured; Interferon-gamma/biosynthesis; Interleukin-18/biosynthesis; Interleukin-18/metabolism; Interleukin-18 Receptor alpha Subunit; Lupus Erythematosus, Systemic/immunology; Lupus Erythematosus, Systemic/metabolism; Lupus Erythematosus, Systemic/pathology; Lymph Nodes/immunology; Lymph Nodes/metabolism; Lymph Nodes/pathology; Lymphocyte Activation; Lymphocyte Subsets/immunology; Lymphocyte Subsets/metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred MRL lpr; RNA, Messenger/biosynthesis; Receptors, Interleukin/genetics; Receptors, Interleukin-18; Spleen/immunology; Spleen/metabolism; Spleen/pathology

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Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Receptors, Interleukin / Interleukin-18 Language: En Journal: J Immunol Year: 2001 Document type: Article Affiliation country: Italy Country of publication: United States

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