Treatment of metastatic breast cancer with somatostatin analogues--a meta-analysis.
Ann Surg Oncol
; 8(3): 227-33, 2001 Apr.
Article
in En
| MEDLINE
| ID: mdl-11314939
BACKGROUND: Somatostatin analogues appear to have antiproliferative effects in breast cancer by inhibiting various hormones. Several small phase 1 and 2 clinical trails have evaluated the efficacy of somatostatin analogues, but the results are varied. The purpose of this study was to use the technique of meta-analysis to determine the effect of somatostatin analogues on tumor response, toxicity, and serum hormone levels in women with metastatic breast cancer. METHODS: All published and unpublished trials were reviewed. Meta-analysis was preformed by best linear unbiased estimate regression with observations weighted inversely to their variance. Significance was considered at P < .05. RESULTS: Fourteen studies (N = 210) were included. Positive tumor response was reported in 87 patients (41.4%). Mean duration of response was 3.9 months. Response was best when somatostatin analogues were given as first-line therapy (69.5% versus 28.5%, P < .006) and in patients with < or =2 metastases (45.0% versus 5.6%, P = .3). Mild side effects occurred in 47 of 185 patients (25.4%). Therapy was associated with a decrease in serum insulin-like growth factor (IGF-1) and an increase in growth hormone. CONCLUSIONS: In patients with metastatic breast cancer, treatment with somatostatin analogues was associated with a tumor response of over 40% with few side effects. Best results were achieved when somatostatin analogues were given as first-line therapy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides, Cyclic
/
Breast Neoplasms
/
Somatostatin
/
Octreotide
/
Antineoplastic Agents, Hormonal
Type of study:
Systematic_reviews
Limits:
Female
/
Humans
Language:
En
Journal:
Ann Surg Oncol
Journal subject:
NEOPLASIAS
Year:
2001
Document type:
Article
Affiliation country:
United States
Country of publication:
United States