Synthesis of GLA-60 type pyran carboxylic acids with an alkyl chain instead of an ester chain as LPS-antagonists.

Watanabe, Y; Miura, K; Shiozaki, M; Kanai, S; Kurakata, S; Nishijima, M

Watanabe, Y; Miura, K; Shiozaki, M; Kanai, S; Kurakata, S; Nishijima, M.

Affiliation

Watanabe Y; Exploratory Chemistry Research Laboratories, Sankyo Co. Ltd., Hiromachi 1-2-58, Shinagawa-ku, 140-8710, Tokyo, Japan.

Carbohydr Res ; 332(3): 257-77, 2001 Jun 04.

Article in En | MEDLINE | ID: mdl-11376606

ABSTRACT

Synthesis of GLA-60 type pyran carboxylic acid analogues with an alkyl chain instead of an ester chain and their LPS-antagonist activity toward human U937 cells are described.

Subject(s)

Lipid A/analogs & derivatives; Lipid A/chemical synthesis; Lipid A/pharmacology; Lipopolysaccharides/antagonists & inhibitors; Adjuvants, Immunologic/chemical synthesis; Carboxylic Acids/chemistry; Combinatorial Chemistry Techniques; Humans; Inhibitory Concentration 50; Lipopolysaccharides/pharmacology; Pyrans/chemistry; Structure-Activity Relationship; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Tumor Necrosis Factor-alpha/biosynthesis; Tumor Necrosis Factor-alpha/drug effects; U937 Cells

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Lipopolysaccharides / Lipid A Limits: Humans Language: En Journal: Carbohydr Res Year: 2001 Document type: Article Affiliation country: Japan Country of publication: Netherlands

Search on Google

Add to My VHL

XML

PubMed Links