Development of potent non-carbohydrate imidazole-based small molecule selectin inhibitors with antiinflammatory activity.

Slee, D H; Romano, S J; Yu, J; Nguyen, T N; John, J K; Raheja, N K; Axe, F U; Jones, T K; Ripka, W C

Slee, D H; Romano, S J; Yu, J; Nguyen, T N; John, J K; Raheja, N K; Axe, F U; Jones, T K; Ripka, W C.

Affiliation

Slee DH; Ontogen Corporation, 2325 Camino Vida Roble, Carlsbad, California, USA. debbie.slee@ontogen.com

J Med Chem ; 44(13): 2094-107, 2001 Jun 21.

Article in En | MEDLINE | ID: mdl-11405647

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis; Imidazoles/chemical synthesis; Imidazoles/pharmacology; Selectins/drug effects; Animals; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Binding Sites/drug effects; CHO Cells; Carbohydrate Sequence; Cell Adhesion/drug effects; Cricetinae; Enzyme-Linked Immunosorbent Assay; Humans; Magnetic Resonance Spectroscopy; Mice; Molecular Sequence Data; Peritonitis/chemically induced; Peritonitis/prevention & control; Thioglycolates

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Collection: 01-internacional Database: MEDLINE Main subject: Anti-Inflammatory Agents, Non-Steroidal / Selectins / Imidazoles Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2001 Document type: Article Affiliation country: United States

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