Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway.

Yao, P M; Tabas, I

Yao, P M; Tabas, I.

Affiliation

Yao PM; Department of Medicine and Anatomy and Cell Biology, Columbia University, New York, New York 10032, USA.

J Biol Chem ; 276(45): 42468-76, 2001 Nov 09.

Article in En | MEDLINE | ID: mdl-11533046

Subject(s)

Apoptosis/drug effects; Cholesterol/toxicity; Macrophages/drug effects; Mitochondria/drug effects; Proto-Oncogene Proteins c-bcl-2; Animals; Arteriosclerosis/pathology; Caspase 9; Caspases/physiology; Cytochrome c Group/metabolism; Glutathione/pharmacology; Macrophages/pathology; Mice; Mice, Inbred C57BL; Mitochondria/physiology; Proto-Oncogene Proteins/biosynthesis; bcl-2-Associated X Protein; fas Receptor/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Cholesterol / Apoptosis / Proto-Oncogene Proteins c-bcl-2 / Macrophages / Mitochondria Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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