N-linked glycosylations at Asn(26) and Asn(114) of human MD-2 are required for toll-like receptor 4-mediated activation of NF-kappaB by lipopolysaccharide.

Ohnishi, T; Muroi, M; Tanamoto, K

Ohnishi, T; Muroi, M; Tanamoto, K.

Affiliation

Ohnishi T; Division of Microbiology, National Institute of Health Sciences, Tokyo, Japan.

J Immunol ; 167(6): 3354-9, 2001 Sep 15.

Article in En | MEDLINE | ID: mdl-11544325

Subject(s)

Acute-Phase Proteins; Antigens, Surface/chemistry; Asparagine/chemistry; Drosophila Proteins; Lipopolysaccharides/pharmacology; Membrane Glycoproteins/physiology; NF-kappa B/metabolism; Receptors, Cell Surface/physiology; Antigens, Surface/physiology; Carrier Proteins/genetics; Carrier Proteins/physiology; Cell Line; Cell Membrane/metabolism; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation/drug effects; Genes, Reporter; Glycosylation; Humans; Kidney; Luciferases/analysis; Luciferases/genetics; Lymphocyte Antigen 96; Mutagenesis, Site-Directed; Protein Binding; Protein Processing, Post-Translational; Protein Transport; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/physiology; Signal Transduction; Structure-Activity Relationship; Toll-Like Receptor 4; Toll-Like Receptors; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Asparagine / Acute-Phase Proteins / Membrane Glycoproteins / Lipopolysaccharides / NF-kappa B / Receptors, Cell Surface / Drosophila Proteins / Antigens, Surface Limits: Humans Language: En Journal: J Immunol Year: 2001 Document type: Article Affiliation country: Japan

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