DNA immunization of HLA transgenic mice with a plasmid expressing mycobacterial heat shock protein 65 results in HLA class I- and II-restricted T cell responses that can be augmented by cytokines.

Charo, J; Sundbäck, M; Geluk, A; Ottenhoff, T; Kiessling, R

Charo, J; Sundbäck, M; Geluk, A; Ottenhoff, T; Kiessling, R.

Affiliation

Charo J; Cancer Center Karolinska, Karolinska Hospital, S-17176, Stockholm, Sweden. Jehad_Charo@nih.gov

Hum Gene Ther ; 12(14): 1797-804, 2001 Sep 20.

Article in En | MEDLINE | ID: mdl-11560772

Subject(s)

Bacterial Proteins; Chaperonins/genetics; Chaperonins/metabolism; Cytokines/metabolism; Genes, MHC Class II/genetics; Genes, MHC Class I/genetics; Mice, Transgenic; Mycobacterium/metabolism; Plasmids/metabolism; T-Lymphocytes/metabolism; Vaccines, DNA; Animals; COS Cells; Cell Division; Chaperonin 60; Epitopes/chemistry; HLA-A2 Antigen/metabolism; Humans; Interferon-gamma/metabolism; Jurkat Cells; Mice; Peptides/chemistry; Protein Binding; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Plasmids / Bacterial Proteins / Genes, MHC Class I / Mice, Transgenic / T-Lymphocytes / Cytokines / Genes, MHC Class II / Chaperonins / Vaccines, DNA / Mycobacterium Limits: Animals / Humans Language: En Journal: Hum Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 2001 Document type: Article Affiliation country: Sweden Country of publication: United States

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