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BCR signals target p27(Kip1) and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells.
Banerji, L; Glassford, J; Lea, N C; Thomas, N S; Klaus, G G; Lam, E W.
Affiliation
  • Banerji L; Ludwig Institute for Cancer Research and Section of Virology and Cell Biology, Imperial College School of Medicine at St Mary's, Norfolk Place, London W2 1PG, UK.
Oncogene ; 20(50): 7352-67, 2001 Nov 01.
Article in En | MEDLINE | ID: mdl-11704865
Subject(s)
Apoptosis/physiology; B-Lymphocytes/pathology; Cell Cycle Proteins/physiology; Cyclins/physiology; DNA-Binding Proteins; G1 Phase/physiology; Phosphatidylinositol 3-Kinases/physiology; Protein Serine-Threonine Kinases; Proteins; Receptors, Antigen, B-Cell/physiology; Signal Transduction/physiology; Tumor Suppressor Proteins/physiology; Antibodies, Anti-Idiotypic/pharmacology; B-Lymphocytes/drug effects; B-Lymphocytes/metabolism; Cell Cycle Proteins/biosynthesis; Cell Cycle Proteins/genetics; Chromones/pharmacology; Cyclin D2; Cyclin-Dependent Kinase Inhibitor p27; Cyclins/biosynthesis; Cyclins/genetics; E2F Transcription Factors; Enzyme Inhibitors/pharmacology; G1 Phase/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Gene Expression Regulation, Neoplastic/physiology; Humans; Lymphoma, B-Cell/pathology; MAP Kinase Signaling System/drug effects; Morpholines/pharmacology; Neoplasm Proteins/antagonists & inhibitors; Neoplasm Proteins/physiology; Nuclear Proteins/physiology; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins/physiology; Phosphorylation/drug effects; Protein Processing, Post-Translational/drug effects; Proto-Oncogene Proteins/physiology; Proto-Oncogene Proteins c-akt; RNA, Messenger/biosynthesis; RNA, Neoplasm/biosynthesis; Recombinant Fusion Proteins/physiology; Retinoblastoma Protein/physiology; Retinoblastoma-Like Protein p107; Retinoblastoma-Like Protein p130; Transcription Factors/antagonists & inhibitors; Tumor Cells, Cultured/drug effects; Tumor Cells, Cultured/metabolism; Tumor Cells, Cultured/pathology
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Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Receptors, Antigen, B-Cell / Signal Transduction / Proteins / G1 Phase / Protein Serine-Threonine Kinases / Apoptosis / Cyclins / Cell Cycle Proteins / Phosphatidylinositol 3-Kinases Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2001 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom
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Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Receptors, Antigen, B-Cell / Signal Transduction / Proteins / G1 Phase / Protein Serine-Threonine Kinases / Apoptosis / Cyclins / Cell Cycle Proteins / Phosphatidylinositol 3-Kinases Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2001 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom