RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice.

Rajan, I; Gestblom, C; Kapur, R P

Rajan, I; Gestblom, C; Kapur, R P.

Affiliation

Rajan I; Department of Pathology, University of Washington, Seattle 98195, USA.

Pediatr Dev Pathol ; 4(5): 446-53, 2001.

Article in En | MEDLINE | ID: mdl-11779046

Subject(s)

Adrenal Gland Neoplasms/genetics; Drosophila Proteins; Ganglioneuroma/genetics; Hirschsprung Disease/genetics; Multiple Endocrine Neoplasia Type 2b/genetics; Proto-Oncogene Proteins/genetics; Receptor Protein-Tyrosine Kinases/genetics; Acetylcholinesterase/analysis; Adrenal Gland Neoplasms/pathology; Animals; Animals, Newborn; Celiac Plexus/pathology; Colon/innervation; DNA/analysis; Disease Models, Animal; Female; Ganglioneuroma/pathology; Glial Cell Line-Derived Neurotrophic Factor Receptors; Hirschsprung Disease/pathology; Hirschsprung Disease/prevention & control; Image Processing, Computer-Assisted; Male; Mice; Mice, Knockout; Mice, Transgenic; Myenteric Plexus/enzymology; Myenteric Plexus/pathology; Polymerase Chain Reaction; Proto-Oncogene Proteins/deficiency; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases/deficiency

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Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins / Receptor Protein-Tyrosine Kinases / Adrenal Gland Neoplasms / Multiple Endocrine Neoplasia Type 2b / Drosophila Proteins / Ganglioneuroma / Hirschsprung Disease Type of study: Prognostic_studies Limits: Animals Language: En Journal: Pediatr Dev Pathol Journal subject: PATOLOGIA / PEDIATRIA Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

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