Caenorhabditis elegans/metabolism; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Endoplasmic Reticulum/metabolism; Membrane Proteins; Protein Serine-Threonine Kinases/metabolism; RNA Splicing; Transcription Factors/genetics; Transcription Factors/metabolism; Animals; Base Sequence; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins/chemistry; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Cell Line; DNA-Binding Proteins/chemistry; Fibroblasts; Introns/genetics; Mice; Molecular Sequence Data; Mutation/genetics; Nucleic Acid Conformation; Protein Denaturation; Protein Folding; Protein Serine-Threonine Kinases/genetics; RNA, Helminth/chemistry; RNA, Helminth/genetics; RNA, Helminth/metabolism; RNA, Messenger/chemistry; RNA, Messenger/genetics; RNA, Messenger/metabolism; Regulatory Factor X Transcription Factors; Stem Cells/metabolism; Transcription Factors/chemistry; X-Box Binding Protein 1