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Secretory carcinoma of the breast: an immunohistochemical and ultrastructural study.
Suzuki, F.; Saito, A.; Ishi, Kazuhisa; Okazaki, Tetsuya; Kina, Katsunari; Koyatsu, Junichi; Sugiyama, Kazuyoshi.
Affiliation
  • Suzuki F; Clinical Laboratory, Juntendo University School of Medicine, Urayasu Hospital, 2-1-1 Tomioka, Urayasu 279-0021, Japan.
Med Electron Microsc ; 32(1): 50-56, 1999 May.
Article in En | MEDLINE | ID: mdl-11810425
Abstract We report a rare case of secretory carcinoma of the breast in a 50-year-old Japanese woman. The patient had been aware of a right breast tumor for 8 years, but had left it untreated. The tumor enlarged in size and became painful, and she visited our hospital. Breast carcinoma was diagnosed, and mastectomy was performed. Histopathological examination revealed features of a secretory carcinoma characterized by prominent secretory activity in the glandular and microcystic spaces, with some areas showing a follicular pattern resembling the thyroid gland. The secretory material was PAS-positive and immunohistochemically alpha-lactalbumin-positive. Ultrastructurally, the tumor cell contained many secretory vacuoles in the cytoplasm. In addition, extracellular and intracytoplasmic lumina were conspicuous; these were lined by microvilli projection and contained secretory material. By flow cytometric analysis, the DNA index was 1.14, which was diploid, showing relatively low proliferative activity.
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Collection: 01-internacional Database: MEDLINE Language: En Journal: Med Electron Microsc Journal subject: MICROBIOLOGIA Year: 1999 Document type: Article Affiliation country: Japan Country of publication: Japan
Search on Google
Collection: 01-internacional Database: MEDLINE Language: En Journal: Med Electron Microsc Journal subject: MICROBIOLOGIA Year: 1999 Document type: Article Affiliation country: Japan Country of publication: Japan