Lack of DNA binding in the rat nasal mucosa and other tissues of the nasal toxicants roflumilast, a phosphodiesterase 4 inhibitor, and a metabolite, 4-amino-3,5-dichloropyridine, in contrast to the nasal carcinogen 2,6-dimethylaniline.

Jeffrey, Alan M; Luo, Feng-Qi; Amin, Shantilal; Krzeminski, Jacek; Zech, Karl; Williams, Gary M

Jeffrey, Alan M; Luo, Feng-Qi; Amin, Shantilal; Krzeminski, Jacek; Zech, Karl; Williams, Gary M.

Affiliation

Jeffrey AM; New York Medical College, Department of Pathology, Valhalla, NY 10595, USA.

Drug Chem Toxicol ; 25(1): 93-107, 2002 Feb.

Article in En | MEDLINE | ID: mdl-11850974

Subject(s)

3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors; Aminopyridines/toxicity; Aniline Compounds/toxicity; Benzamides/toxicity; DNA Adducts/drug effects; Nasal Mucosa/drug effects; Pyridines/toxicity; Aminopyridines/chemistry; Aminopyridines/metabolism; Aniline Compounds/chemical synthesis; Animals; Benzamides/chemistry; Benzamides/metabolism; Carcinogens/toxicity; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; DNA/chemistry; DNA/drug effects; DNA/genetics; Hydroxybenzoates/chemistry; Male; Molecular Structure; Mutagenicity Tests; Mutagens/toxicity; Nasal Mucosa/metabolism; Phosphorus Radioisotopes; Pyridines/chemical synthesis; Rats; Rats, Wistar

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Benzamides / 3',5'-Cyclic-AMP Phosphodiesterases / DNA Adducts / Aminopyridines / Aniline Compounds / Nasal Mucosa Limits: Animals Language: En Journal: Drug Chem Toxicol Year: 2002 Document type: Article Affiliation country: United States Country of publication: United States

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