Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases.

Kessler, Fay K; Kessler, Marissa R; Auyeung, Diana J; Ritter, Joseph K

Kessler, Fay K; Kessler, Marissa R; Auyeung, Diana J; Ritter, Joseph K.

Affiliation

Kessler FK; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298-0613, USA.

Drug Metab Dispos ; 30(3): 324-30, 2002 Mar.

Article in En | MEDLINE | ID: mdl-11854153

Subject(s)

Acetaminophen/metabolism; Analgesics/metabolism; Glucuronosyltransferase/metabolism; Acetaminophen/adverse effects; Analgesics/adverse effects; Animals; Blotting, Western; Catalysis; Cells, Cultured; Chromatography, High Pressure Liquid; Enzyme Induction; Glucuronosyltransferase/biosynthesis; Glucuronosyltransferase/genetics; Hepatocytes/metabolism; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver/enzymology; Molecular Sequence Data; Pyrazines/pharmacology; Rats; Rats, Gunn; Rats, Sprague-Dawley; Recombinant Proteins/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Thiones; Thiophenes

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Collection: 01-internacional Database: MEDLINE Main subject: Glucuronosyltransferase / Analgesics / Acetaminophen Limits: Animals / Humans / Male Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2002 Document type: Article Affiliation country: United States Country of publication: United States

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