Lysophospholipids induce membrane hyperpolarization in microglia by activation of IKCa1 Ca(2+)-dependent K(+) channels.

Schilling, T; Repp, H; Richter, H; Koschinski, A; Heinemann, U; Dreyer, F; Eder, C

Schilling, T; Repp, H; Richter, H; Koschinski, A; Heinemann, U; Dreyer, F; Eder, C.

Affiliation

Schilling T; Institute of Physiology, Humboldt University, Berlin, Germany.

Neuroscience ; 109(4): 827-35, 2002.

Article in En | MEDLINE | ID: mdl-11927165

Subject(s)

Brain/metabolism; Calcium Signaling/physiology; Calcium/metabolism; Cell Membrane/metabolism; Lysophospholipids/metabolism; Microglia/metabolism; Potassium Channels/metabolism; Sphingosine/analogs & derivatives; Animals; Animals, Newborn; Brain/cytology; Brain/drug effects; Brain Chemistry/drug effects; Brain Chemistry/physiology; Calcium Signaling/drug effects; Cell Membrane/drug effects; Cells, Cultured; Charybdotoxin/pharmacology; Gliosis/metabolism; Gliosis/physiopathology; Intermediate-Conductance Calcium-Activated Potassium Channels; Lysophospholipids/pharmacology; Membrane Potentials/drug effects; Membrane Potentials/physiology; Mice; Mice, Inbred Strains; Microglia/drug effects; Peptides/pharmacology; Potassium Channels/drug effects; Potassium Channels/genetics; RNA, Messenger/drug effects; RNA, Messenger/metabolism; Sphingosine/metabolism; Sphingosine/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Sphingosine / Brain / Lysophospholipids / Potassium Channels / Cell Membrane / Calcium / Microglia / Calcium Signaling Limits: Animals Language: En Journal: Neuroscience Year: 2002 Document type: Article Affiliation country: Germany Country of publication: United States

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