Relevant role of Leu265 in helix VI of the angiotensin AT1 receptor in agonist binding and activity.

Correa, Silvana Aparecida Alves; França, Lucimar Pereira; Costa-Neto, Claudio Miguel; Oliveira, Laerte; Paiva, Antonio Cechelli Mattos; Shimuta, Suma Imura

Correa, Silvana Aparecida Alves; França, Lucimar Pereira; Costa-Neto, Claudio Miguel; Oliveira, Laerte; Paiva, Antonio Cechelli Mattos; Shimuta, Suma Imura.

Affiliation

Correa SA; Department of Biophysics, Universidade Federal de São Paulo, Escola Paulista de Medicina, Brazil.

Can J Physiol Pharmacol ; 80(5): 426-30, 2002 May.

Article in En | MEDLINE | ID: mdl-12056549

Subject(s)

Leucine/chemistry; Receptors, Angiotensin/agonists; Receptors, Angiotensin/chemistry; Amino Acid Sequence/physiology; Amino Acid Substitution/physiology; Animals; Binding Sites/physiology; CHO Cells; Cricetinae; Leucine/genetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin/genetics; Receptors, Angiotensin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Angiotensin / Leucine Limits: Animals Language: En Journal: Can J Physiol Pharmacol Year: 2002 Document type: Article Affiliation country: Brazil Country of publication: Canada

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