Hypoxic induction of the hypoxia-inducible factor is mediated via the adaptor protein Shc in endothelial cells.

Jung, Frank; Haendeler, Judith; Hoffmann, Jörg; Reissner, Agnes; Dernbach, Elisabeth; Zeiher, Andreas M; Dimmeler, Stefanie

Jung, Frank; Haendeler, Judith; Hoffmann, Jörg; Reissner, Agnes; Dernbach, Elisabeth; Zeiher, Andreas M; Dimmeler, Stefanie.

Affiliation

Jung F; Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany.

Circ Res ; 91(1): 38-45, 2002 Jul 12.

Article in En | MEDLINE | ID: mdl-12114320

Subject(s)

Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; DNA-Binding Proteins/metabolism; Endothelium, Vascular/metabolism; Nuclear Proteins/metabolism; Proteins/metabolism; Transcription Factors; Blotting, Western; Cell Hypoxia/physiology; Cell Line; Cell Movement/drug effects; Cobalt/pharmacology; Cycloheximide/pharmacology; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects; Enzyme Inhibitors/pharmacology; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mutation; Plasmids/genetics; Proteins/genetics; Proto-Oncogene Proteins c-raf/antagonists & inhibitors; Proto-Oncogene Proteins c-raf/metabolism; Pyrazoles/pharmacology; Pyrimidines/pharmacology; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transfection; Tyrphostins/pharmacology; Ubiquitin/metabolism; ras Proteins/genetics; ras Proteins/metabolism; src-Family Kinases/antagonists & inhibitors; src-Family Kinases/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Endothelium, Vascular / Nuclear Proteins / Proteins / Adaptor Proteins, Vesicular Transport / Adaptor Proteins, Signal Transducing / DNA-Binding Proteins Limits: Humans Language: En Journal: Circ Res Year: 2002 Document type: Article Affiliation country: Germany

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