The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis.

Kagari, Takashi; Doi, Hiromi; Shimozato, Takaichi

Kagari, Takashi; Doi, Hiromi; Shimozato, Takaichi.

Affiliation

Kagari T; Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan. tkagar@shina.sankyo.ac.jp

J Immunol ; 169(3): 1459-66, 2002 Aug 01.

Article in En | MEDLINE | ID: mdl-12133972

Subject(s)

Antibodies, Monoclonal/immunology; Arthritis/etiology; Interleukin-1/physiology; Interleukin-6/physiology; Tumor Necrosis Factor-alpha/physiology; Animals; Arthritis/pathology; Arthritis/prevention & control; Chemokine CCL2/biosynthesis; Chemokine CCL2/genetics; Chemokine CXCL2; Chemokines/biosynthesis; Chemokines/genetics; Collagen Type II/immunology; Interleukin-1/genetics; Interleukin-6/genetics; Male; Mice; Mice, Inbred BALB C; Mice, SCID; RNA, Messenger/analysis; Receptors, Interleukin-1/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Arthritis / Interleukin-6 / Interleukin-1 / Tumor Necrosis Factor-alpha / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Immunol Year: 2002 Document type: Article Affiliation country: Japan Country of publication: United States

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