Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase.

Hamm, Jorg; Alessi, Dario R; Biondi, Ricardo M

Hamm, Jorg; Alessi, Dario R; Biondi, Ricardo M.

Affiliation

Hamm J; Department of Biochemistry, University of Dundee, Dundee, United Kingdom. jorg.hamm@unito.it

J Biol Chem ; 277(48): 45793-802, 2002 Nov 29.

Article in En | MEDLINE | ID: mdl-12235136

Subject(s)

Cyclic AMP Response Element-Binding Protein/metabolism; Magnesium/metabolism; RNA/metabolism; Ribosomal Protein S6 Kinases, 90-kDa/metabolism; Base Sequence; Cell Line; DNA Primers; Humans; Molecular Mimicry; Nucleic Acid Conformation; Phosphorylation; Protein Conformation; RNA/chemistry; Recombinant Proteins/metabolism; Ribosomal Protein S6 Kinases, 90-kDa/chemistry; Substrate Specificity; Surface Plasmon Resonance

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Collection: 01-internacional Database: MEDLINE Main subject: RNA / Cyclic AMP Response Element-Binding Protein / Ribosomal Protein S6 Kinases, 90-kDa / Magnesium Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2002 Document type: Article Affiliation country: United kingdom

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