Vitamin C induced decomposition of lipid hydroperoxides: direct evidence of genotoxin-DNA binding detected by QCRS.

Pavey, K D; Miah, M; Fucassi, F; Paul, F; Cragg, P J

Pavey, K D; Miah, M; Fucassi, F; Paul, F; Cragg, P J.

Affiliation

Pavey KD; School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewes Road, Brighton, UK BN2 4GJ. K.D.Pavey@bton.ac.uk

Chem Commun (Camb) ; (18): 1886-7, 2001 Sep 21.

Article in En | MEDLINE | ID: mdl-12240363

ABSTRACT

We report direct evidence for human DNA-binding to precursors of mutagenic lesion-inducing compounds, produced form the vitamin C induced decomposition of lipid hydroperoxides, using a quartz crystal resonant sensor assay.

Subject(s)

Ascorbic Acid/pharmacology; DNA/metabolism; Lipid Peroxides/metabolism; Mutagens/metabolism; DNA Damage; Humans; Quartz; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Ascorbic Acid / DNA / Lipid Peroxides / Mutagens Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2001 Document type: Article Country of publication: United kingdom

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