Protamine sulfate titration for heparin activity in neonates with indwelling umbilical catheters.

A rapid, simple, semimicro method for neutralization of heparin effect by titration with protamine sulfate is described. Protamine sulfate can be effectively employed to eliminate the effect of heparin on the APTT. Determination of true abnormalities of coagulation has important prognostic and therapeutic implications for the sick newborn infant.