Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction.

Dayal, Sanjana; Brown, Kara L; Weydert, Christine J; Oberley, Larry W; Arning, Erland; Bottiglieri, Teodoro; Faraci, Frank M; Lentz, Steven R

Dayal, Sanjana; Brown, Kara L; Weydert, Christine J; Oberley, Larry W; Arning, Erland; Bottiglieri, Teodoro; Faraci, Frank M; Lentz, Steven R.

Affiliation

Dayal S; Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA.

Arterioscler Thromb Vasc Biol ; 22(12): 1996-2002, 2002 Dec 01.

Article in En | MEDLINE | ID: mdl-12482825

Subject(s)

Endothelium, Vascular/enzymology; Endothelium, Vascular/physiopathology; Ethidium/analogs & derivatives; Glutathione Peroxidase/deficiency; Glutathione Peroxidase/genetics; Hyperhomocysteinemia/enzymology; Hyperhomocysteinemia/genetics; Animals; Aorta, Thoracic/drug effects; Aorta, Thoracic/enzymology; Carotid Arteries/chemistry; Carotid Arteries/drug effects; Carotid Arteries/enzymology; Catalase/metabolism; Diet; Ethidium/analysis; Glutathione Peroxidase/blood; Homocysteine/blood; Hyperhomocysteinemia/blood; Liver/enzymology; Methionine/blood; Methionine/metabolism; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Superoxide Dismutase/metabolism; Superoxides/analysis; Vasomotor System/drug effects; Vasomotor System/enzymology; Glutathione Peroxidase GPX1

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Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Hyperhomocysteinemia / Ethidium / Glutathione Peroxidase Limits: Animals Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2002 Document type: Article Affiliation country: United States

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