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[Oesophageal cancer in patients with head and neck cancers: therapeutic implications]. / Association cancers de l'oesophage et des voies aérodigestives supérieures : implications thérapeutiques.
Mariette, C; Fabre, S; Balon, J M; Finzi, L; Chevalier, D; Triboulet, J P.
Affiliation
  • Mariette C; Service de chirurgie digestive et générale, hôpital Claude-Huriez, CHRU, place de Verdun, 59037 Lille cedex, France.
Ann Chir ; 127(10): 757-64, 2002 Dec.
Article in Fr | MEDLINE | ID: mdl-12538096
AIM OF THE STUDY: To determine therapeutic and prognostic implications of an associated head and neck primary cancer in patients undergoing oesophagectomy for squamous cell carcinoma of the oesophagus. PATIENTS AND METHODS: Between 1982 and 2000, 868 patients with oesophageal cancer were operated in our institution, including 78 (9%) who underwent oesophagectomy for associated oesophageal and head and neck cancers; the latter was synchronous (n = 52) or anterior metachronous (n = 26). Influence of head and neck cancer on the treatment of oesophageal carcinoma was analysed retrospectively in terms of surgical therapeutic strategy and survival. RESULTS: Oesophageal resection consisted of oeso-pharyngolaryngectomy (n = 14, 17.9%), subtotal oesophagectomy (n = 62, 79.5%) and cervical oesophagectomy (n = 2, 2.6%). Radical resection (R0) was obtained in 85% of cases. Postoperative mortality rate was 5 % (4/78). Main complications were pulmonary (18% = 14/78) and anastomotic leaks (14% = 11/78), all of them cervical. Follow-up (mean = 25 +/- 27 months) was complete for all 78 patients. Five-year survival after R0 resection was 25%. Survival pronostic factors were denutrition, complete resection, and pT status of oesophageal tumor. CONCLUSION: In patients with associated carcinomas of oesophagus and head and neck, agressive treatment -including an oesophagectomy- allowed a 5-year survival rate more than 25% without increased mortality or morbidity rates, compared with patients operated on for isolated oesophageal carcinoma.
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Collection: 01-internacional Database: MEDLINE Main subject: Esophageal Neoplasms / Carcinoma, Squamous Cell / Neoplasms, Second Primary / Head and Neck Neoplasms / Neoplasms, Multiple Primary Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: Fr Journal: Ann Chir Year: 2002 Document type: Article Affiliation country: France Country of publication: France
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Collection: 01-internacional Database: MEDLINE Main subject: Esophageal Neoplasms / Carcinoma, Squamous Cell / Neoplasms, Second Primary / Head and Neck Neoplasms / Neoplasms, Multiple Primary Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: Fr Journal: Ann Chir Year: 2002 Document type: Article Affiliation country: France Country of publication: France