[Paracetamol overdose and experimental cholestasis induced gene expression regulation that codified P-Glycoprotein type 1 in rats].

Ghanem, Carolina; Gomez, Paula C; Arana, Cecilia; Bengochea, Laura

[Paracetamol overdose and experimental cholestasis induced gene expression regulation that codified P-Glycoprotein type 1 in rats]. / La sobredosis de paracetamol y la colestasis experimental inducen la expresión de los genes que codifican la P-glicoprotína tipo 1 en ratas.

Ghanem, Carolina; Gomez, Paula C; Arana, Cecilia; Bengochea, Laura.

Affiliation

Ghanem C; Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires.

Acta Gastroenterol Latinoam ; 32(2): 79-82, 2002.

Article in Es | MEDLINE | ID: mdl-12553158

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics; Acetaminophen/toxicity; Analgesics, Non-Narcotic/toxicity; Chemical and Drug Induced Liver Injury; Cholestasis, Extrahepatic/chemically induced; Gene Expression Regulation; Genes, MDR/genetics; ATP Binding Cassette Transporter, Subfamily B, Member 1/drug effects; Acetaminophen/metabolism; Acute Disease; Analgesics, Non-Narcotic/metabolism; Animals; Bile/metabolism; Blotting, Northern; Carrier Proteins/metabolism; Cholestasis, Extrahepatic/metabolism; Disease Models, Animal; Drug Overdose; Gene Expression Regulation/drug effects; Genes, MDR/drug effects; Hepatocytes; Liver Diseases/metabolism; Male; RNA, Messenger/metabolism; Rats; Rats, Wistar

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Collection: 01-internacional Database: MEDLINE Main subject: Cholestasis, Extrahepatic / Gene Expression Regulation / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Analgesics, Non-Narcotic / Genes, MDR / Chemical and Drug Induced Liver Injury / Acetaminophen Limits: Animals Language: Es Journal: Acta Gastroenterol Latinoam Year: 2002 Document type: Article Country of publication: Argentina

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