ortho-Halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity.

Ghelli, Stefano; Rinaldi, Marcella; Barlocco, Daniela; Gelain, Arianna; Pecorari, Piergiorgio; Tondi, Donatella; Rastelli, Giulio; Costi, Maria Paola

Ghelli, Stefano; Rinaldi, Marcella; Barlocco, Daniela; Gelain, Arianna; Pecorari, Piergiorgio; Tondi, Donatella; Rastelli, Giulio; Costi, Maria Paola.

Affiliation

Ghelli S; Dipartimento di Chimica, Universita' degli Studi di Modena e Reggio Emilia, Via Campi 183 41100, Modena, Italy.

Bioorg Med Chem ; 11(6): 951-63, 2003 Mar 20.

Article in En | MEDLINE | ID: mdl-12614880

Subject(s)

Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Hydrocarbons, Halogenated/chemical synthesis; Hydrocarbons, Halogenated/pharmacology; Lacticaseibacillus casei/enzymology; Naphthalenes/chemical synthesis; Naphthalenes/pharmacology; Thymidylate Synthase/antagonists & inhibitors; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Protein Conformation; Quantum Theory; Spectrometry, Mass, Electrospray Ionization

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Thymidylate Synthase / Enzyme Inhibitors / Hydrocarbons, Halogenated / Lacticaseibacillus casei / Naphthalenes Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2003 Document type: Article Affiliation country: Italy Country of publication: United kingdom

Search on Google

Add to My VHL

XML

PubMed Links