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Effect of alpha-tocopherol on the oxidative modification of apolipoprotein E in human very-low-density lipoprotein.
Arai, Hirofumi; Uchida, Koji; Fukunaga, Kenji; Nagasaka, Yuji; Mohri, Satoshi; Furumoto, Hiroko; Kuramitsu, Yasuhiro; Nakamura, Kazuyuki.
Affiliation
  • Arai H; Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine, Ube 755-8505, Japan.
Biosci Biotechnol Biochem ; 67(2): 402-5, 2003 Feb.
Article in En | MEDLINE | ID: mdl-12729008
The oxidative modification of apolipoprotein (apo) E and lipid peroxidation in human very-low-density lipoprotein (VLDL) induced by peroxynitrite and cupric ions in vitro were strongly suppressed by enrichment with alpha-tocopherol (alpha-Toc; 170 microM). Alpha-Toc also suppressed the decrease in the heparin-binding activity of apoE in the VLDL oxidation. These results suggest that alpha-Toc protected apoE in VLDL from oxidative stress.
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Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins E / Molsidomine / Alpha-Tocopherol / Lipoproteins, VLDL Limits: Humans Language: En Journal: Biosci Biotechnol Biochem Journal subject: BIOQUIMICA / BIOTECNOLOGIA Year: 2003 Document type: Article Affiliation country: Japan Country of publication: United kingdom
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Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins E / Molsidomine / Alpha-Tocopherol / Lipoproteins, VLDL Limits: Humans Language: En Journal: Biosci Biotechnol Biochem Journal subject: BIOQUIMICA / BIOTECNOLOGIA Year: 2003 Document type: Article Affiliation country: Japan Country of publication: United kingdom