Radiation-induced deletions in the 5' end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas.

Tsuji, Hideo; Ishii-Ohba, Hiroko; Ukai, Hideki; Katsube, Takanori; Ogiu, Toshiaki

Tsuji, Hideo; Ishii-Ohba, Hiroko; Ukai, Hideki; Katsube, Takanori; Ogiu, Toshiaki.

Affiliation

Tsuji H; Low Dose Radiation Effects Research Project Group, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555, Japan. tsujihid@nirs.go.jp

Carcinogenesis ; 24(7): 1257-68, 2003 Jul.

Article in En | MEDLINE | ID: mdl-12807718

Subject(s)

DNA/radiation effects; Gene Deletion; Homeodomain Proteins; Lymphoma/genetics; Membrane Proteins/genetics; Neoplasms, Radiation-Induced/genetics; Receptors, Cell Surface; Thymus Neoplasms/genetics; Transcription Factors; Amino Acid Sequence; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Transformation, Viral/genetics; DNA Primers/chemistry; DNA, Neoplasm/metabolism; Gene Expression Regulation, Neoplastic; Gene Rearrangement/genetics; Lymphoma/virology; Mice; Mice, Inbred ICR; Mice, SCID; Molecular Sequence Data; Morphogenesis; Muscle Proteins/genetics; Muscle Proteins/metabolism; Mutagenesis, Insertional; RNA, Messenger/analysis; RNA, Messenger/chemistry; RNA, Neoplasm/metabolism; Receptor, Notch1; Reverse Transcriptase Polymerase Chain Reaction; Thymus Neoplasms/virology; Transcription Factor HES-1

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Collection: 01-internacional Database: MEDLINE Main subject: Thymus Neoplasms / Transcription Factors / DNA / Gene Deletion / Receptors, Cell Surface / Homeodomain Proteins / Lymphoma / Membrane Proteins / Neoplasms, Radiation-Induced Type of study: Prognostic_studies Limits: Animals Language: En Journal: Carcinogenesis Year: 2003 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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