Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs).

Brooke, Edward W; Davies, Stephen G; Mulvaney, Andrew W; Okada, Minoru; Pompeo, Frédérique; Sim, Edith; Vickers, Richard J; Westwood, Isaac M

Brooke, Edward W; Davies, Stephen G; Mulvaney, Andrew W; Okada, Minoru; Pompeo, Frédérique; Sim, Edith; Vickers, Richard J; Westwood, Isaac M.

Affiliation

Brooke EW; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.

Bioorg Med Chem Lett ; 13(15): 2527-30, 2003 Aug 04.

Article in En | MEDLINE | ID: mdl-12852958

Subject(s)

Arylamine N-Acetyltransferase/antagonists & inhibitors; Bacteria/enzymology; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Alkylation; Bacteria/drug effects; Indicators and Reagents; Kinetics; Models, Molecular; Molecular Conformation; Mycobacterium smegmatis/drug effects; Mycobacterium smegmatis/enzymology; Salmonella typhimurium/drug effects; Salmonella typhimurium/enzymology; Structure-Activity Relationship

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Arylamine N-Acetyltransferase / Bacteria / Enzyme Inhibitors Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2003 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

Search on Google

Add to My VHL

XML

PubMed Links