Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.

Pryce, Gareth; Ahmed, Zubair; Hankey, Deborah J R; Jackson, Samuel J; Croxford, J Ludovic; Pocock, Jennifer M; Ledent, Catherine; Petzold, Axel; Thompson, Alan J; Giovannoni, Gavin; Cuzner, M Louise; Baker, David

Pryce, Gareth; Ahmed, Zubair; Hankey, Deborah J R; Jackson, Samuel J; Croxford, J Ludovic; Pocock, Jennifer M; Ledent, Catherine; Petzold, Axel; Thompson, Alan J; Giovannoni, Gavin; Cuzner, M Louise; Baker, David.

Affiliation

Pryce G; Department of Neuroinflammation, Institute of Neurology, University College London, London, UK.

Brain ; 126(Pt 10): 2191-202, 2003 Oct.

Article in En | MEDLINE | ID: mdl-12876144

Subject(s)

Aspartic Acid/analogs & derivatives; Cannabinoids/therapeutic use; Multiple Sclerosis/drug therapy; Saccharomyces cerevisiae Proteins; Animals; Aspartic Acid/analysis; Axons/chemistry; Axons/pathology; Benzoxazines; Cyclohexanols/therapeutic use; Dizocilpine Maleate/therapeutic use; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acid Agonists/therapeutic use; Gene Deletion; Humans; Mice; Mice, Transgenic; Monomeric GTP-Binding Proteins/genetics; Morpholines/therapeutic use; Multiple Sclerosis/pathology; N-Methylaspartate/therapeutic use; Naphthalenes/therapeutic use; Nerve Degeneration; Nuclear Proteins/genetics; Receptors, Cannabinoid; Receptors, Drug/agonists; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Retina/drug effects; Retina/pathology; Spinal Cord/pathology; Uveitis/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Cannabinoids / Aspartic Acid / Saccharomyces cerevisiae Proteins / Multiple Sclerosis Limits: Animals / Humans Language: En Journal: Brain Year: 2003 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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