Fluorescence imaging analysis of upstream regulators and downstream targets of STAT3 in melanoma precursor lesions obtained from patients before and after systemic low-dose interferon-alpha treatment.

Smith, Amanda Pfaff; Kirkwood, John M; Edington, Howard D; Jukic, Drazen M; Farkas, Daniel L; Becker, Dorothea

Smith, Amanda Pfaff; Kirkwood, John M; Edington, Howard D; Jukic, Drazen M; Farkas, Daniel L; Becker, Dorothea.

Affiliation

Smith AP; University of Pittsburgh, 211 Lothrop Street, Pittsburgh, PA 15213, USA.

Mol Imaging ; 2(1): 65-73, 2003 Jan.

Article in En | MEDLINE | ID: mdl-12926238

Subject(s)

DNA-Binding Proteins/metabolism; Interferon-alpha/therapeutic use; Melanoma/drug therapy; Melanoma/metabolism; Microscopy, Fluorescence/methods; Precancerous Conditions/drug therapy; Precancerous Conditions/metabolism; Proto-Oncogene Proteins; Skin Neoplasms/drug therapy; Skin Neoplasms/metabolism; Trans-Activators/metabolism; Humans; In Vitro Techniques; Interferon alpha-2; Interferon-alpha/administration & dosage; Janus Kinase 2; Melanoma/pathology; Membrane Proteins; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases/metabolism; NF-kappa B/metabolism; Precancerous Conditions/pathology; Protein Serine-Threonine Kinases/metabolism; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins c-akt; Receptor, Interferon alpha-beta; Receptors, Interferon/metabolism; Recombinant Proteins; STAT1 Transcription Factor; STAT3 Transcription Factor; Skin Neoplasms/pathology

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Collection: 01-internacional Database: MEDLINE Main subject: Precancerous Conditions / Skin Neoplasms / Trans-Activators / Proto-Oncogene Proteins / Interferon-alpha / DNA-Binding Proteins / Melanoma / Microscopy, Fluorescence Limits: Humans Language: En Journal: Mol Imaging Journal subject: DIAGNOSTICO POR IMAGEM Year: 2003 Document type: Article Affiliation country: United States Country of publication: United kingdom

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