A model for amyloid fibril formation in immunoglobulin light chains based on comparison of amyloidogenic and benign proteins and specific antibody binding.

Khurana, Ritu; Souillac, Pierre O; Coats, Alisa C; Minert, Lauren; Ionescu-Zanetti, Cristian; Carter, Sue A; Solomon, Alan; Fink, Anthony L

Khurana, Ritu; Souillac, Pierre O; Coats, Alisa C; Minert, Lauren; Ionescu-Zanetti, Cristian; Carter, Sue A; Solomon, Alan; Fink, Anthony L.

Affiliation

Khurana R; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.

Amyloid ; 10(2): 97-109, 2003 Jun.

Article in En | MEDLINE | ID: mdl-12964417

Subject(s)

Amyloid/chemistry; Amyloidosis/metabolism; Antibodies, Monoclonal/chemistry; Immunoglobulin Light Chains/chemistry; Amyloid/immunology; Amyloid/metabolism; Amyloidosis/immunology; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal/metabolism; Binding Sites, Antibody/immunology; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Immunoglobulin Light Chains/immunology; Immunoglobulin Light Chains/metabolism; Immunoglobulin Variable Region/chemistry; Immunoglobulin Variable Region/immunology; Immunoglobulin Variable Region/metabolism; Kinetics; Microscopy, Atomic Force; Models, Chemical; Models, Molecular; Protein Conformation; Recombinant Proteins/chemistry; Recombinant Proteins/immunology; Recombinant Proteins/metabolism; Spectroscopy, Fourier Transform Infrared

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Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Light Chains / Amyloid / Amyloidosis / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Amyloid Journal subject: BIOQUIMICA Year: 2003 Document type: Article Affiliation country: United States

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