Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides.

Youssefyeh, R D; Campbell, H F; Klein, S; Airey, J E; Darkes, P; Powers, M; Schnapper, M; Neuenschwander, K; Fitzpatrick, L R; Pendley, C E

Youssefyeh, R D; Campbell, H F; Klein, S; Airey, J E; Darkes, P; Powers, M; Schnapper, M; Neuenschwander, K; Fitzpatrick, L R; Pendley, C E.

Affiliation

Youssefyeh RD; Rhône-Poulenc Rorer Central Research, King of Prussia, Pennsylvania 19406.

J Med Chem ; 35(5): 895-903, 1992 Mar 06.

Article in En | MEDLINE | ID: mdl-1312602

Subject(s)

Antiemetics/chemical synthesis; Benzamides/chemical synthesis; Benzofurans/chemical synthesis; Bridged Bicyclo Compounds, Heterocyclic; Bridged Bicyclo Compounds/chemical synthesis; Serotonin Antagonists; Animals; Antiemetics/pharmacology; Antiemetics/therapeutic use; Benzamides/pharmacology; Benzamides/therapeutic use; Benzofurans/pharmacology; Benzofurans/therapeutic use; Binding, Competitive; Bridged Bicyclo Compounds/pharmacology; Bridged Bicyclo Compounds/therapeutic use; Cerebral Cortex/metabolism; Cisplatin/toxicity; Ferrets; Granisetron; Imidazoles/metabolism; Imidazoles/pharmacology; Imidazoles/therapeutic use; Indazoles/pharmacology; Indazoles/therapeutic use; Indoles/metabolism; Male; Metoclopramide/pharmacology; Metoclopramide/therapeutic use; Molecular Structure; Ondansetron; Rats; Receptors, Serotonin/metabolism; Structure-Activity Relationship; Vomiting/chemically induced; Vomiting/prevention & control

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Collection: 01-internacional Database: MEDLINE Main subject: Serotonin Antagonists / Benzamides / Benzofurans / Bridged Bicyclo Compounds / Bridged Bicyclo Compounds, Heterocyclic / Antiemetics Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1992 Document type: Article Country of publication: United States

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