Platelet-activating factor inhibits proteoglycan synthesis and enhances neutrophil-mediated proteoglycan degradation in cartilage explants.

Kowanko, I C; Bates, E J; Ferrante, A

Kowanko, I C; Bates, E J; Ferrante, A.

Affiliation

Kowanko IC; Department of Immunology, Adelaide Children's Hospital, Australia.

Arthritis Rheum ; 35(8): 918-25, 1992 Aug.

Article in En | MEDLINE | ID: mdl-1322671

Subject(s)

Cartilage, Articular/metabolism; Neutrophils/physiology; Platelet Activating Factor/pharmacology; Platelet Membrane Glycoproteins; Proteoglycans/metabolism; Receptors, G-Protein-Coupled; Animals; Azepines/pharmacology; Cartilage, Articular/cytology; Cartilage, Articular/ultrastructure; Cattle; Cells, Cultured; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology; Phospholipid Ethers/pharmacology; Platelet Activating Factor/antagonists & inhibitors; Pyridinium Compounds/pharmacology; Receptors, Cell Surface/antagonists & inhibitors; Receptors, Cell Surface/drug effects; Sulfur Radioisotopes; Triazoles/pharmacology; Tumor Necrosis Factor-alpha/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Proteoglycans / Platelet Activating Factor / Platelet Membrane Glycoproteins / Cartilage, Articular / Receptors, G-Protein-Coupled / Neutrophils Limits: Animals Language: En Journal: Arthritis Rheum Year: 1992 Document type: Article Affiliation country: Australia Country of publication: United States

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