Wood creosote, the principal active ingredient of seirogan, an herbal antidiarrheal medicine: a single-dose, dose-escalation safety and pharmacokinetic study.

Kuge, Tomoo; Shibata, Takashi; Willett, Michael S

Kuge, Tomoo; Shibata, Takashi; Willett, Michael S.

Affiliation

Kuge T; Taiko Pharmaceutical Company, Ltd, Suita-City, Osaka, Japan. kuge@seirogan.co.jp

Pharmacotherapy ; 23(11): 1391-400, 2003 Nov.

Article in En | MEDLINE | ID: mdl-14620385

Subject(s)

Antidiarrheals/pharmacokinetics; Creosote/pharmacokinetics; Plant Extracts/pharmacokinetics; Plant Preparations/pharmacokinetics; Wood; Adult; Antidiarrheals/administration & dosage; Antidiarrheals/adverse effects; Area Under Curve; Blood Pressure/drug effects; Blood Pressure/physiology; Creosote/administration & dosage; Creosote/adverse effects; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Heart Rate/drug effects; Heart Rate/physiology; Humans; Linear Models; Male; Plant Extracts/administration & dosage; Plant Extracts/adverse effects; Plant Preparations/administration & dosage; Plant Preparations/adverse effects

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Collection: 01-internacional Database: MEDLINE Main subject: Wood / Plant Extracts / Creosote / Plant Preparations / Antidiarrheals Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Pharmacotherapy Year: 2003 Document type: Article Affiliation country: Japan Country of publication: United States

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