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Aggressive management of orbital meningeal melanocytoma.
de Tella, O I; Agner, C; Aguiar, P H; Herculano, M A; Prandini, M N; Stavile, J N.
Affiliation
  • de Tella OI; Department of Neurosurgery, Federal University of Sao Paulo, Sao Paulo, Brazil.
Acta Neurochir (Wien) ; 145(12): 1121-6, 2003 Dec.
Article in En | MEDLINE | ID: mdl-14663571
OBJECTIVE: Meningeal melanocytoma generally occurs in the posterior fossa. Orbital manifestation is rarely encountered. METHODS: A thirty-five year-old man presented with progressive proptosis of his right eye. Computed tomography (CT) and Magnetic Resonance Imaging (MRI) of the brain showed an expansive intraconal mass lesion occupying the superior orbital compartment, the entire orbital apex, and the optic foramen. Histological analysis and Immunohistochemical staining for S-100 and HMB-45 monoclonal antibodies confirmed melanocytoma. FINDINGS: Microsurgical removal was accomplished through a fronto-orbital craniotomy. Chemotherapy and irradiation followed the initial intervention. The patient returned for follow up two years after surgery, complaining of headache and right visual loss. A subfrontal tumor with massive edema was found on follow up CT scan. INTERPRETATION: Meningeal melanocytomas are rare benign pigmented tumors of the central nervous system. They are predominant in the posterior fossa and spinal cord and frequently mistaken for melanomas, especially on frozen sections. Orbital presentation is rare. The natural history is poorly defined.
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Collection: 01-internacional Database: MEDLINE Main subject: Orbital Neoplasms / Meningeal Neoplasms / Nevus Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Humans / Male Language: En Journal: Acta Neurochir (Wien) Year: 2003 Document type: Article Affiliation country: Brazil Country of publication: Austria
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Collection: 01-internacional Database: MEDLINE Main subject: Orbital Neoplasms / Meningeal Neoplasms / Nevus Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Humans / Male Language: En Journal: Acta Neurochir (Wien) Year: 2003 Document type: Article Affiliation country: Brazil Country of publication: Austria