Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.

Batty, Ian H; Fleming, Ian N; Downes, C Peter

Batty, Ian H; Fleming, Ian N; Downes, C Peter.

Affiliation

Batty IH; The Division of Cell Signalling, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow St, Dundee DD1 5EH, Scotland, UK. i.h.batty@dundee.ac.uk

Biochem J ; 379(Pt 3): 641-51, 2004 May 01.

Article in En | MEDLINE | ID: mdl-14769130

Subject(s)

Astrocytoma/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Receptor, IGF Type 1/antagonists & inhibitors; Receptors, Muscarinic/metabolism; Signal Transduction; Astrocytoma/pathology; Calcium/metabolism; Carbachol/pharmacology; Cell Line, Tumor; Enzyme Activation/drug effects; Humans; Inositol 1,4,5-Trisphosphate/metabolism; Insulin/pharmacology; Insulin Receptor Substrate Proteins; Ionomycin/pharmacology; Mitogen-Activated Protein Kinases/metabolism; Okadaic Acid/pharmacology; Phosphoproteins/metabolism; Phosphorylation/drug effects; Phosphoserine/metabolism; Phosphotyrosine/metabolism; Platelet-Derived Growth Factor/pharmacology; Protein Kinase C/metabolism; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1/metabolism; Ribosomal Protein S6 Kinases, 70-kDa/metabolism; Signal Transduction/drug effects; Tetradecanoylphorbol Acetate/pharmacology; Type C Phospholipases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Astrocytoma / Signal Transduction / Receptors, Muscarinic / Receptor, IGF Type 1 / Phosphatidylinositol 3-Kinases Limits: Humans Language: En Journal: Biochem J Year: 2004 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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