Enhancing immunogenicity and reducing dose of microparticulated synthetic vaccines: single intradermal administration.

Carcaboso, Angel M; Hernández, Rosa M; Igartua, Manuela; Rosas, Jaiver E; Patarroyo, Manuel E; Pedraz, José L

Carcaboso, Angel M; Hernández, Rosa M; Igartua, Manuela; Rosas, Jaiver E; Patarroyo, Manuel E; Pedraz, José L.

Affiliation

Carcaboso AM; Pharmacy and Pharmaceutical Technology Laboratory, Faculty of Pharmacy, University of the Basque Country (UPV-EHU), Paseo de la Universidad no 7, 01006 Vitoria-Gasteiz, Spain.

Pharm Res ; 21(1): 121-6, 2004 Jan.

Article in En | MEDLINE | ID: mdl-14984266

Subject(s)

Adjuvants, Immunologic/administration & dosage; Microspheres; Vaccines, Subunit/administration & dosage; Vaccines, Subunit/immunology; Vaccines, Synthetic/administration & dosage; Vaccines, Synthetic/immunology; Animals; Cell Division/immunology; Dose-Response Relationship, Immunologic; Drug Administration Schedule; Injections, Intradermal; Injections, Subcutaneous; Lactic Acid/administration & dosage; Lactic Acid/immunology; Lymphocyte Activation/immunology; Lymphocytes/cytology; Lymphocytes/drug effects; Lymphocytes/immunology; Mice; Mice, Inbred BALB C; Particle Size; Polyglycolic Acid/administration & dosage; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers/administration & dosage; Spleen/drug effects; Spleen/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Vaccines, Synthetic / Adjuvants, Immunologic / Vaccines, Subunit / Microspheres Limits: Animals Language: En Journal: Pharm Res Year: 2004 Document type: Article Affiliation country: Spain Country of publication: United States

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