Ligand-induced changes in the conformational dynamics of a bacterial cytotoxic endonuclease.

van den Bremer, Ewald T J; Keeble, Anthony H; Visser, Antonie J W G; van Hoek, Arie; Kleanthous, Colin; Heck, Albert J R; Jiskoot, Wim

van den Bremer, Ewald T J; Keeble, Anthony H; Visser, Antonie J W G; van Hoek, Arie; Kleanthous, Colin; Heck, Albert J R; Jiskoot, Wim.

Affiliation

van den Bremer ET; Department of Biomolecular Mass Spectrometry, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands.

Biochemistry ; 43(14): 4347-55, 2004 Apr 13.

Article in En | MEDLINE | ID: mdl-15065879

Subject(s)

Bacterial Proteins; Bacterial Toxins/chemistry; Colicins/chemistry; Deoxyribonucleases/chemistry; Bacterial Toxins/genetics; Binding Sites/genetics; Colicins/genetics; Deoxyribonucleases/antagonists & inhibitors; Deoxyribonucleases/genetics; Fluorescence Polarization; Ligands; Mutagenesis, Site-Directed; Phenylalanine/genetics; Protein Conformation; Protein Structure, Tertiary/genetics; Solvents; Spectrometry, Fluorescence; Thermodynamics; Tryptophan/genetics; Zinc/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Bacterial Toxins / Colicins / Deoxyribonucleases Language: En Journal: Biochemistry Year: 2004 Document type: Article Affiliation country: Netherlands Country of publication: United States

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