Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence.

Kamran, Mohammed; Calcagno, Ana-Maria; Findon, Helen; Bignell, Elaine; Jones, Michael D; Warn, Peter; Hopkins, Philip; Denning, David W; Butler, Geraldine; Rogers, Thomas; Mühlschlegel, Fritz A; Haynes, Ken

Kamran, Mohammed; Calcagno, Ana-Maria; Findon, Helen; Bignell, Elaine; Jones, Michael D; Warn, Peter; Hopkins, Philip; Denning, David W; Butler, Geraldine; Rogers, Thomas; Mühlschlegel, Fritz A; Haynes, Ken.

Affiliation

Kamran M; Department of Infectious Diseases, Imperial College London, London.

Eukaryot Cell ; 3(2): 546-52, 2004 Apr.

Article in En | MEDLINE | ID: mdl-15075283

Subject(s)

Candida glabrata/pathogenicity; Candidiasis/microbiology; Fungal Proteins/physiology; Transcription Factors/physiology; Alleles; Animals; Candida glabrata/genetics; Candidiasis/pathology; Chitinases/pharmacology; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Fungal Proteins/genetics; Fungal Proteins/metabolism; Gene Silencing; Interferon-gamma/analysis; Interferon-gamma/metabolism; Interleukin-6/analysis; Interleukin-6/metabolism; Liver/pathology; Lung/pathology; Mice; Phenotype; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism; Tumor Necrosis Factor-alpha/analysis; Tumor Necrosis Factor-alpha/metabolism; Virulence

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Candidiasis / Fungal Proteins / Candida glabrata Type of study: Prognostic_studies Limits: Animals Language: En Journal: Eukaryot Cell Journal subject: BIOLOGIA MOLECULAR Year: 2004 Document type: Article

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