Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues.

Castillo, S Sianna; Brognard, John; Petukhov, Pavel A; Zhang, Chunyu; Tsurutani, Junji; Granville, Courtney A; Li, Min; Jung, Michael; West, Kip A; Gills, Joell G; Kozikowski, Alan P; Dennis, Phillip A

Castillo, S Sianna; Brognard, John; Petukhov, Pavel A; Zhang, Chunyu; Tsurutani, Junji; Granville, Courtney A; Li, Min; Jung, Michael; West, Kip A; Gills, Joell G; Kozikowski, Alan P; Dennis, Phillip A.

Affiliation

Castillo SS; Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

Cancer Res ; 64(8): 2782-92, 2004 Apr 15.

Article in En | MEDLINE | ID: mdl-15087394

Subject(s)

Phosphatidylinositols/pharmacology; Phospholipid Ethers/pharmacology; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins/antagonists & inhibitors; Antineoplastic Agents/pharmacology; Carcinoma, Non-Small-Cell Lung/drug therapy; Carcinoma, Non-Small-Cell Lung/enzymology; Carcinoma, Non-Small-Cell Lung/genetics; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors/pharmacology; Humans; Hydrogen-Ion Concentration; Insulin-Like Growth Factor I/pharmacology; Kinetics; Lung Neoplasms/drug therapy; Lung Neoplasms/enzymology; Lung Neoplasms/genetics; Models, Molecular; Protein Structure, Tertiary; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Structure-Activity Relationship; Substrate Specificity; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphatidylinositols / Phospholipid Ethers / Proto-Oncogene Proteins / Protein Serine-Threonine Kinases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cancer Res Year: 2004 Document type: Article Affiliation country: United States Country of publication: United States

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